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alternative therapeutic options should be considered for these patients [seeBoxed WarningandUse in Specific Populations (8.1)]

While weight loss is often linked to a negative impact on PD severity [181], another study suggests that PD progression is faster in patients with metabolic syndrome [182]

In this review, we are focusing on translational biomarkers that can be detected in biofluids since biofluids can be easily obtained in the clinic

[20] In 1985, biosynthetic human growth hormone replaced pituitary-derived human growth hormone for therapeutic use in the U.S

doi: 10.1007/s00125-007-0604-5 67 TajimaSIkedaYSawadaKYamanoNHorinouchiYKihiraYet al